This paper will argue for a meta-semiotic perspective based on an interdisciplinary inquiry of semiotics and theology, one that offers a fresh perspective and relevancy for both traditions. For political, historical, theoretical and cultural reasons, semiotics as a child of modernity has had a steadfastly secular focus, seeking to explain, in terms of human behaviour and culture, phenomena that were previously attributed to supernatural causation. Theology has retained a basis in apologetics and dogma, a pursuit of truth that can seem at odds with the scientific, empirical and philosophical assumptions of semiotics. In brief semiotics has been focused on epistemology, theology on ontology. For these traditions to merge, both need to be progressive, inclusive, and broadened. Theology needs to become more philosophical, ecumenical and generalist in approach: semiotics needs to be open to non-human and naturalist motivation, and deepened ethical and truth based approach to human behaviour. The result of a semiotic/theology interdisciplinary merger could be enriching for both traditions, and indeed essential to their contemporary development and relevance.